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NG,NG-dimethyl-L-Arginine dihydrochloride

Name: NG,NG-dimethyl-L-Arginine dihydrochloride
Brand: TargetMol
SKU: T21546
Price: -1 USD
Availability: InStock
Rating: 5 (10 reviews)

产品编号 T21546Cas号 220805-22-1

别名 不对称二甲基精氨酸二盐酸盐

NG,NG-dimethyl-L-Arginine dihydrochloride 是一种内源性一氧化氮合酶抑制剂。由 L-精氨酸合成的一氧化氮 (NO) 有助于调节血压和宿主防御。

为众多的药物研发团队赋能，

让新药发现更简单！

NG,NG-dimethyl-L-Arginine dihydrochloride

纯度: 99.18%

产品编号 T21546 别名 不对称二甲基精氨酸二盐酸盐Cas号 220805-22-1

NG,NG-dimethyl-L-Arginine dihydrochloride 是一种内源性一氧化氮合酶抑制剂。由 L-精氨酸合成的一氧化氮 (NO) 有助于调节血压和宿主防御。

规格	价格	库存
1 mg	¥ 218	现货
5 mg	¥ 600	现货
10 mg	¥ 1,080	现货
50 mg	询价	5日内发货
1 mL x 10 mM (in DMSO)	¥ 880	现货

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"NG,NG-dimethyl-L-Arginine dihydrochloride"的相关化合物库

神经保护化合物库

Neuroprotective Compound Library

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NO PAINS 化合物库

NO PAINS Compound Library

L40209384 化合物

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经典已知活性库

Bioactive Compound Library

L400017100 化合物

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已知活性化合物库

Bioactive Compounds Library Max

L401025682 化合物

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抑制剂库

Inhibitor Library

L20009730 化合物

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选择批次:

纯度:99.18%

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资源下载

COA LCMS HNMR 产品操作手册

TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

产品介绍

生物活性

产品描述	NG,NG-dimethyl-L-Arginine dihydrochloride is an endogenous nitric oxide synthase inhibitor. Nitric oxide (NO) that is synthesised from L-arginine contributes to the regulation of blood pressure and to host defence[1].
体外活性	NG,NG-dimethyl-L-Arginine (ADMA) was found to be able to inhibit macrophage and vascular NO synthase. When added to a cytosolic preparation of macrophage NO synthase, ADMA could cause dose-dependent inhibition of NO formation. In the presence of added arginine, ADMA could inhibited NO synthesis and the inhibitory effects of ADMA were prevented by addition of L-arginine so that the rate of NO synthesis did not significantly differ from control values [1].
体内活性	Animal study showed that the injection of 1-30 mg/kg ADMA into 3 anaesthetised guineapigs could cause dose-dependent increases in mean arterial blood pressure. Moreover, during continuous infusion of ADMA, which caused plasma ADMA concentrations to rise approximately 9-fold, the systolic blood pressure was raised by nearly 15 % [1].
别名	不对称二甲基精氨酸二盐酸盐

化学信息

分子量	275.18
分子式	C₈H₂₀Cl₂N₄O₂
CAS No.	220805-22-1

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

Ethanol: 11 mg/mL (39.97 mM)

DMSO: 7 mg/mL (25.43 mM)

H2O: 14 mg/mL (50.87 mM)

溶液配制表

DMSO/Ethanol/H2O

	1mg	5mg	10mg	50mg
1 mM	3.6340 mL	18.1699 mL	36.3399 mL	181.6993 mL
5 mM	0.7268 mL	3.6340 mL	7.2680 mL	36.3399 mL
10 mM	0.3634 mL	1.8170 mL	3.6340 mL	18.1699 mL
20 mM	0.1817 mL	0.9085 mL	1.8170 mL	9.0850 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， TargetMol | Animal experiments

一共给药动物 10 只 ，您使用的配方为 5% TargetMol | reagent

DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL 。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLddH2O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

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NG,NG-dimethyl-L-Arginine dihydrochloride

NG,NG-dimethyl-L-Arginine dihydrochloride

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产品介绍

计算器

体内实验配液计算器

剂量转换

关键词